A simple, primary amine bearing a C10H15 alkyl residue was found to display potent anti-
Influenza A properties in 1964. 1 Soon thereafter, antiviral activity of this amine was found …

The recent outbreaks of avian influenza A (H5N1) virus, its expanding geographic
distribution and its ability to transfer to humans and cause severe infection have raised …

Alkyl radicals generated via an acridine photocatalyzed decarboxylation reaction of
feedstock carboxylic acids engage with a range of cyclic imine–BF3 complexes to provide α …

The chemistry of organic polycyclic cage compounds has intrigued medicinal chemists for
over 50 years, yet little is published about their pharmacological profiles. Polycyclic cage …

Chemotherapy and chemoprophylaxis of influenza is one of the most important directions of
health protection activity. Due to the high rate of drug-resistant strains of influenza virus …

2-(1-Adamantyl)-2-methyl-pyrrolidines 3 and 4, 2-(1-adamantyl)-2-methyl-azetidines 5 and
6, and 2-(1-adamantyl)-2-methyl-aziridines 7 and 8 were synthesized and tested for their …

Amantadine has been used for decades as an inhibitor of the influenza A virus M2 protein
(AM2) in the prophylaxis and treatment of influenza A infections, but its clinical use has been …

Spiro [aziridine-2, 2′-adamantanes] 1 and 2, spiro [azetidine-2, 2′-adamantanes] 3 and 5,
spiro [azetidine-3, 2′-adamantane] 13, spiro [piperidine-4, 2′-adamantanes] 25 and 27 …

Since 1997, several epizootic avian influenza viruses (AIVs) have been transmitted to
humans, causing diseases and even deaths. The recent emergence of severe human …

Inflammation is the complex biological response of vascular tissues, which is partly
determined by prostaglandins (PLA 2). The cyclooxygenase (COX) enzyme exists in two …