Dopamine (DA) transmission is governed by processes that regulate release from axonal
boutons in the forebrain and the somatodendritic compartment in midbrain, and by …

Enhancement of brain-derived neurotrophic factor (BDNF) signalling has great potential in
therapy for neurological and psychiatric disorders. This neurotrophin not only attenuates cell …

Physical exercise improves motor performance in individuals with Parkinson9s disease and
elevates mood in those with depression. Although underlying factors have not been …

Angelman Syndrome (AS) is a severe cognitive disorder caused by loss of neuronal
expression of the E3 ubiquitin ligase UBE3A. In an AS mouse model, we previously reported …

Brain ageing leads to atrophy and degeneration of the cholinergic nervous system, resulting
in profound neurobehavioral and cognitive dysfunction from decreased acetylcholine …

Fragile X syndrome (FXS) is a common cause of inherited intellectual disability and a well‐
characterized form of autism spectrum disorder. As brain‐derived neurotrophic factor …

Designer receptors exclusively activated by designer drugs (DREADDs) are novel and
powerful tools to investigate discrete neuronal populations in the brain. We have used …

Brain-derived neurotrophic factor (BDNF) is a crucial regulator of neuroplasticity, which
underlies learning and memory processes in different brain areas. To investigate the role of …

Fragile X syndrome (FXS) is a monogenic disorder that is caused by the absence of FMR1
protein (FMRP). FXS serves as an excellent model disorder for studies investigating …

A molecular and functional link between neurotrophin signaling and cerebellar foliation is
lacking. Here we show that constitutive knockout of two homologous genes encoding the …