Polyphosphoinositides (PPIs) are essential phospholipids located in the cytoplasmic leaflet
of eukaryotic cell membranes. Despite contributing only a small fraction to the bulk of cellular …

Subarachnoid hemorrhage (SAH) can lead to devastating neurological outcomes, and there
are few pharmacologic treatments available for treating this condition. Both animal and …

Subarachnoid hemorrhage (SAH) is a devastating stroke subtype with a high rate of
mortality and morbidity. The poor clinical outcome can be attributed to the biphasic course of …

Aneurysmal subarachnoid hemorrhage (aSAH) is one of the most severe neurological
disorders, with a high mortality rate and severe disabling functional sequelae. Systemic …

Nonsteroidal anti-inflammatory drugs are among the most commonly administered drugs in
the perioperative period due to their prominent role in pain management. However, they …

Highlights•Smooth muscle dysfunction underlies many disorders.•KCNQ-genes are
expressed in smooth muscle as well as in brain and heart.•Enhancing KV 7 channels …

Objective—Middle cerebral artery (MCA) diameter is regulated by inherent myogenic activity
and the effect of potent vasodilators such as calcitonin gene-related peptide (CGRP) …

Smooth muscle cells provide crucial contractile functions in visceral, vascular, and lung
tissues. The contractile state of smooth muscle is largely determined by their electrical …

The Kv7 family (Kv7. 1–7.5) of voltage-activated potassium channels contributes to the
maintenance of resting membrane potential in excitable cells. Previously, we provided …

The response of the blood–brain barrier (BBB) following a stroke, including subarachnoid
hemorrhage (SAH), has been studied extensively. The main components of this reaction are …