Multicomponent peptide assemblies

DM Raymond, BL Nilsson - Chemical Society Reviews, 2018 - pubs.rsc.org
Self-assembled peptide nanostructures have been increasingly exploited as functional
materials for applications in biomedicine and energy. The emergent properties of these …

What macromolecular crowding can do to a protein

IM Kuznetsova, KK Turoverov, VN Uversky - International journal of …, 2014 - mdpi.com
The intracellular environment represents an extremely crowded milieu, with a limited amount
of free water and an almost complete lack of unoccupied space. Obviously, slightly salted …

Tau protein liquid–liquid phase separation can initiate tau aggregation

S Wegmann, B Eftekharzadeh, K Tepper… - The EMBO …, 2018 - embopress.org
The transition between soluble intrinsically disordered tau protein and aggregated tau in
neurofibrillary tangles in Alzheimer's disease is unknown. Here, we propose that soluble tau …

Phosphorylation-mediated RNA/peptide complex coacervation as a model for intracellular liquid organelles

WM Aumiller Jr, CD Keating - Nature chemistry, 2016 - nature.com
Biological cells are highly organized, with numerous subcellular compartments.
Phosphorylation has been hypothesized as a means to control the assembly/disassembly of …

Thermodynamically driven assemblies and liquid–liquid phase separations in biology

H Falahati, A Haji-Akbari - Soft matter, 2019 - pubs.rsc.org
The sustenance of life depends on the high degree of organization that prevails through
different levels of living organisms, from subcellular structures such as biomolecular …

Macromolecular cryoprotectants for the preservation of mammalian cell culture: lessons from crowding, overview and perspectives

M Gore, A Narvekar, A Bhagwat, R Jain… - Journal of Materials …, 2022 - pubs.rsc.org
Cryopreservation is a process used for the storage of mammalian cells at a very low
temperature, in a state of 'suspended animation.'Highly effective and safe macromolecular …

Experimental models for dynamic compartmentalization of biomolecules in liquid organelles: Reversible formation and partitioning in aqueous biphasic systems

WM Aumiller Jr, CD Keating - Advances in colloid and interface science, 2017 - Elsevier
Living cells contain numerous subcellular compartments, many of which lack membranous
boundaries and are thought to occur due to liquid–liquid phase coexistence. This review will …

Molecular dissection of nuclear paraspeckles: towards understanding the emerging world of the RNP milieu

S Nakagawa, T Yamazaki… - Royal Society Open …, 2018 - royalsocietypublishing.org
Paraspeckles are nuclear bodies built on an architectural long noncoding RNA, NEAT1, and
a series of studies have revealed their molecular components, fine internal structures and …

Interactions of macromolecular crowding agents and cosolutes with small-molecule substrates: effect on horseradish peroxidase activity with two different substrates

WM Aumiller Jr, BW Davis, E Hatzakis… - The Journal of …, 2014 - ACS Publications
The importance of solution composition on enzymatic reactions is increasingly appreciated,
particularly with respect to macromolecular cosolutes. Macromolecular crowding and its …

Marangoni Droplets of Dextran in PEG Solution and Its Motile Change Due to Coil–Globule Transition of Coexisting DNA

T Furuki, H Sakuta, N Yanagisawa… - … Applied Materials & …, 2024 - ACS Publications
Motile droplets using Marangoni convection are attracting attention for their potential as cell-
mimicking small robots. However, the motion of droplets relative to the internal and external …