These prophetic words, written by Reverend Edward Stone in a 1763 letter to George
Parker, the second Earl of Macclesfield, describe the results of the first clinical trial recorded …

Oral antiplatelet drugs are a cornerstone of modern pharmacotherapy in cardiovascular
atherothrombotic diseases. The efficacy of acetylsalicylic acid (ASA, aspirin) and clopidogrel …

Background and Purpose—Aspirin resistance may be relatively common and associated
with adverse outcome. Meta-analysis has clearly shown that 75 mg plain aspirin is the …

Aspirin is effective in the prevention of cardiovascular events in high-risk patients. The
primary established effect of aspirin on hemostasis is to impair platelet aggregation via …

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• A genetic basis for aspirin resistance
has been postulated to exist.• The individual studies published have been too small to allow …

The definition 'resistance to antiplatelet drugs' should be limited to situations in which failure
of the drug to hit its pharmacological target has been documented by specific laboratory …

follows activation of the enzyme phospholipase A2. On release, arachidonic acid is rapidly
metabolized by prostaglandin (PG) H2 synthase, also known as cyclooxygenase (COX) …

The two most widely used antiplatelet drugs in the world are aspirin and clopidogrel.
However, some patients on aspirin and/or clopidogrel therapy do not respond appropriately …

Background—The inability of aspirin (acetylsalicylic acid [ASA]) to adequately suppress
platelet function is associated with future risk of myocardial infarction, stroke, and …

Aspirin affords cardioprotection through the acetylation of serine529 in human
cyclooxygenase-1 (COX-1) of anucleated platelets, inducing a permanent defect in …