Much has been learned since the early 1960s about histone post-translational modifications
(PTMs) and how they affect DNA-templated processes at the molecular level. This …

Recent studies on mutations in cancer genomes have distinguished driver mutations from
passenger mutations, which occur as byproducts of cancer development. The cancer …

DNA replication timing and three-dimensional (3D) genome organization are associated
with distinct epigenome patterns across large domains. However, whether alterations in the …

Alzheimer's disease (AD) is the most common neurodegenerative disease, which severely
threatens the health of the elderly and causes significant economic and social burdens. The …

Background & Aims Wnt signaling contributes to the development of colorectal cancer
(CRC). We studied interactions between lysine demethylase 4D (KDM4D or JMJD2D) and β …

Histone post-translational modifications (HPTMs), as one of the core mechanisms of
epigenetic regulation, are garnering increasing attention due to their close association with …

Inactivation of the VHL (Von Hippel Lindau) tumour suppressor has long been recognised
as necessary for the pathogenesis of clear cell renal cancer (ccRCC); however, the …

Growing evidence has demonstrated that epigenetic dysregulation is a common
pathological feature in human cancer cells. Global alterations in the epigenetic landscape …

In eukaryotic genomes, hundreds to thousands of potential start sites of DNA replication
named origins are dispersed across each of the linear chromosomes. During S-phase, only …

DNA replication follows a strict spatiotemporal program that intersects with chromatin
structure but has a poorly understood genetic basis. To systematically identify genetic …