Quinoxaline: An insight into the recent pharmacological advances

S Tariq, K Somakala, M Amir - European Journal of Medicinal Chemistry, 2018 - Elsevier
Quinoxaline, a fused heterocycle of benzene and pyrazine rings has gained considerable
attention in the field of contemporary medicinal chemistry. The moiety is of substantial …

Recent advances in the transition-metal-free synthesis of quinoxalines

B Borah, LR Chowhan - RSC advances, 2021 - pubs.rsc.org
Quinoxalines, also known as benzo [a] pyrazines, constitute an important class of nitrogen-
containing heterocyclic compounds as a result of their widespread prevalence in natural …

Ultrasound-assisted transition-metal-free catalysis: a sustainable route towards the synthesis of bioactive heterocycles

B Borah, LR Chowhan - RSC advances, 2022 - pubs.rsc.org
Heterocycles of synthetic and natural origin are a well-established class of compounds
representing a broad range of organic molecules that constitute over 60% of drugs and …

Present status of quinoxaline motifs: Excellent pathfinders in therapeutic medicine

OO Ajani - European journal of medicinal chemistry, 2014 - Elsevier
Quinoxalines belong to a class of excellent heterocyclic scaffolds owing to their wide
biological properties and diverse therapeutic applications in medicinal research. They are …

New structural classes of antimalarials

GK Rathod, M Jain, KK Sharma, S Das, A Basak… - European journal of …, 2022 - Elsevier
Malaria remains a major vector borne disease claiming millions of lives worldwide due to
infections caused by Plasmodium sp. Discovery and development of antimalarial drugs have …

Selective activity against Mycobacterium tuberculosis of new quinoxaline 1, 4-di-N-oxides

E Vicente, S Pérez-Silanes, LM Lima, S Ancizu… - Bioorganic & medicinal …, 2009 - Elsevier
New series of 3-phenylquinoxaline 1, 4-di-N-oxide with selective activity against
Mycobacterium tuberculosis have been prepared and evaluated. Thirty-four of the seventy …

Quinoxaline 1, 4-dioxides: advances in chemistry and chemotherapeutic drug development

GI Buravchenko, AE Shchekotikhin - Pharmaceuticals, 2023 - mdpi.com
N-Oxides of heterocyclic compounds are the focus of medical chemistry due to their diverse
biological properties. The high reactivity and tendency to undergo various rearrangements …

Fluorinated scaffolds for antimalarial drug discovery

C Upadhyay, M Chaudhary… - Expert Opinion on …, 2020 - Taylor & Francis
Introduction The unique physicochemical properties and chemical diversity of
organofluorine compounds have remarkably contributed for their wide utility in the area of …

Progress in quinoxaline synthesis (Part 2)

VA Mamedov, NA Zhukova - Progress in heterocyclic chemistry, 2013 - Elsevier
In the second part of this two-part review (for Part 1 see VA Mamedov, A. Nataliya, NA
Zhukova, Prog. Heterocycl. Chem. 2012, 24, 55), recent advances in the synthesis of …

Recent advances in design of potential quinoxaline anti-infectives

J Jampilek - Current medicinal chemistry, 2014 - ingentaconnect.com
Antimicrobial diazanaphthalenes are indispensable in the treatment of various infections.
The quinoxaline scaffold possesses unique physicochemical properties and provides a …