Pharmacogenetics is the study of how interindividual variations in the DNA sequence of
specific genes affect drug response. This article highlights current pharmacogenetic …

A global resurgence of malaria has taken place as a result of a lapse in preventive efforts
and the emergence of resistance to standard antimalarial drugs. New therapies are …

The present study evaluates the worldwide frequency distribution of CYP2C19 alleles and
CYP2C19 metabolic phenotypes ('predicted'from genotypes and 'measured'with a probe …

CYP2C9 and CYP2C19 are important drug metabolizing enzymes and together metabolize
about 18% of currently available drugs. Some of the important groups of drugs that are …

Proton pump inhibitors (PPIs) are extensively metabolized in the liver by CYP2C19, that
demonstrates genetic polymorphism with 21 mutant alleles. The subjects can be divided into …

Abstract The Cytochrome P450 (CYP450) family of enzymes is involved in the oxidative
metabolism of many therapeutic drugs, carcinogens and various endogenous substrates …

Efavirenz and proguanil are likely to be administered concurrently for the treatment of
patients with HIV and malaria. The metabolism of proguanil is mediated principally by …

Interindividual differences in response to drug treatments are mainly caused by differences
in drug metabolism, in which cytochrome P450 (CYP450) enzymes are involved. Genetic …

CYP2C19 is a polymorphic enzyme which metabolizes several clinically important drugs
including proguanil. Variation in the 5? regulatory region may influence CYP2C19 activity …