Psychological mechanisms and functions of 5-HT and SSRIs in potential therapeutic change: Lessons from the serotonergic modulation of action selection, learning …

C Roberts, BJ Sahakian, TW Robbins - Neuroscience & biobehavioral …, 2020 - Elsevier
Uncertainty regarding which psychological mechanisms are fundamental in mediating SSRI
treatment outcomes and wide-ranging variability in their efficacy has raised more questions …

Serotonergic modulation across sensory modalities

TR Sizemore, LM Hurley… - Journal of …, 2020 - journals.physiology.org
The serotonergic system has been widely studied across animal taxa and different functional
networks. This modulatory system is therefore well positioned to compare the consequences …

TDP-43 promotes tau accumulation and selective neurotoxicity in bigenic Caenorhabditis elegans

CS Latimer, JG Stair, JC Hincks… - Disease Models & …, 2022 - journals.biologists.com
Although amyloid β (Aβ) and tau aggregates define the neuropathology of Alzheimer's
disease (AD), TDP-43 has recently emerged as a co-morbid pathology in more than half of …

Distinct neurexin isoforms cooperate to initiate and maintain foraging activity

BL Bastien, MH Cowen, MP Hart - Translational Psychiatry, 2023 - nature.com
Neurexins are synaptic adhesion molecules that play diverse roles in synaptic development,
function, maintenance, and plasticity. Neurexin genes have been associated with changes …

Pongamol Prevents Neurotoxicity via the Activation of MAPKs/Nrf2 Signaling Pathway in H2O2-Induced Neuronal PC12 Cells and Prolongs the Lifespan of …

S Wu, J Miao, S Zhu, X Wu, J Shi, J Zhou, Y Xing… - Molecular …, 2024 - Springer
Despite tremendous advances in modern medicine, effective prevention or therapeutic
strategies for age-related neurodegenerative diseases such as Alzheimer's disease (AD) …

Molecular and circuit mechanisms underlying avoidance of rapid cooling stimuli in C. elegans

C Lin, Y Shan, Z Wang, H Peng, R Li, P Wang… - Nature …, 2024 - nature.com
The mechanisms by which animals respond to rapid changes in temperature are largely
unknown. Here, we found that polymodal ASH sensory neurons mediate rapid cooling …

Graphical-model framework for automated annotation of cell identities in dense cellular images

S Chaudhary, SA Lee, Y Li, DS Patel, H Lu - Elife, 2021 - elifesciences.org
Although identifying cell names in dense image stacks is critical in analyzing functional
whole-brain data enabling comparison across experiments, unbiased identification is very …

Modulation by NPY/NPF-like receptor underlies experience-dependent, sexually dimorphic learning

S Peedikayil-Kurien, R Haque, A Gat… - Nature …, 2025 - nature.com
The evolutionary paths taken by each sex within a given species sometimes diverge,
resulting in behavioral differences. Given their distinct needs, the mechanism by which each …

Reproductive toxicity of enrofloxacin in Caenorhabditis elegans involves oxidative stress-induced cell apoptosis

J Huang, L Liao, G Wang, Z Du, Z Wu - Journal of Environmental Sciences, 2023 - Elsevier
Fluoroquinolone antibiotics (FQs) that persist and bioaccumulate in the environment have
aroused people's great concern. Here, we studied the adverse effects of FQs in soil animals …

Methylmercury-Induced Metabolic Alterations in Caenorhabditis elegans Are Diet-Dependent

N Crawford, M Martell, T Nielsen, B Khalil, F Imtiaz… - Toxics, 2021 - mdpi.com
Methylmercury (MeHg) is a well-known neurotoxicant; however, its role in metabolic
diseases has been gaining wider attention. Chronic exposure to MeHg in human …