Regulation of nuclear mechanics and the impact on DNA damage
Á Dos Santos, CP Toseland - International Journal of Molecular Sciences, 2021 - mdpi.com
In eukaryotic cells, the nucleus houses the genomic material of the cell. The physical
properties of the nucleus and its ability to sense external mechanical cues are tightly linked …
properties of the nucleus and its ability to sense external mechanical cues are tightly linked …
Genetic and epigenetic determinants of DNA replication origins, position and activation
M Méchali, K Yoshida, P Coulombe… - Current opinion in genetics …, 2013 - Elsevier
In the genome of eukaryotic cells, DNA synthesis is initiated at multiple sites called origins of
DNA replication. Origins must fire only once per cell cycle and how this is achieved is now …
DNA replication. Origins must fire only once per cell cycle and how this is achieved is now …
PTEN regulates DNA replication progression and stalled fork recovery
J He, X Kang, Y Yin, KSC Chao, WH Shen - Nature communications, 2015 - nature.com
Faithful DNA replication is a cornerstone of genomic integrity. PTEN plays multiple roles in
genome protection and tumour suppression. Here we report on the importance of PTEN in …
genome protection and tumour suppression. Here we report on the importance of PTEN in …
Highly organized DnaA– oriC complexes recruit the single-stranded DNA for replication initiation
S Ozaki, T Katayama - Nucleic acids research, 2012 - academic.oup.com
In Escherichia coli, the replication origin oriC consists of two functional regions: the duplex
unwinding element (DUE) and its flanking DnaA-assembly region (DAR). ATP-DnaA …
unwinding element (DUE) and its flanking DnaA-assembly region (DAR). ATP-DnaA …
Replication timing and its emergence from stochastic processes
J Bechhoefer, N Rhind - Trends in Genetics, 2012 - cell.com
The temporal organization of DNA replication has puzzled cell biologists since before the
mechanism of replication was understood. The realization that replication timing correlates …
mechanism of replication was understood. The realization that replication timing correlates …
Chromatin structure and replication origins: determinants of chromosome replication and nuclear organization
OK Smith, MI Aladjem - Journal of Molecular Biology, 2014 - Elsevier
The DNA replication program is, in part, determined by the epigenetic landscape that
governs local chromosome architecture and directs chromosome duplication. Replication …
governs local chromosome architecture and directs chromosome duplication. Replication …
Chromatin unfolding by Cdt1 regulates MCM loading via opposing functions of HBO1 and HDAC11-geminin
PG Wong, MA Glozak, TV Cao, C Vaziri, E Seto… - Cell Cycle, 2010 - Taylor & Francis
The efficiency of metazoan origins of DNA replication is known to be enhanced by histone
acetylation near origins. Although this correlates with increased MCM recruitment, the …
acetylation near origins. Although this correlates with increased MCM recruitment, the …
[HTML][HTML] Loss of NEIL3 DNA glycosylase markedly increases replication associated double strand breaks and enhances sensitivity to ATR inhibitor in glioblastoma …
AW Klattenhoff, M Thakur, CS Chu, D Ray, SL Habib… - Oncotarget, 2017 - ncbi.nlm.nih.gov
DNA endonuclease eight-like glycosylase 3 (NEIL3) is one of the DNA glycosylases that
removes oxidized DNA base lesions from single-stranded DNA (ssDNA) and non-B DNA …
removes oxidized DNA base lesions from single-stranded DNA (ssDNA) and non-B DNA …
Hsp90@ chromatin. nucleus: an emerging hub of a networker
R Sawarkar, R Paro - Trends in cell biology, 2013 - cell.com
The molecular chaperone heat-shock protein of 90 kDa (Hsp90) stabilizes various proteins
and occupies a central position in cellular networks. Hsp90 inhibitors are being tested in …
and occupies a central position in cellular networks. Hsp90 inhibitors are being tested in …
Nuclear α1-antichymotrypsin promotes chromatin condensation and inhibits proliferation of human hepatocellular carcinoma cells
M Santamaria, A Pardo–Saganta, L Alvarez–Asiain… - Gastroenterology, 2013 - Elsevier
BACKGROUND & AIMS: α1-Antichymotrypsin (α1-ACT), a member of the serpin family
(SERPINA3), is an acute-phase protein secreted by hepatocytes in response to cytokines …
(SERPINA3), is an acute-phase protein secreted by hepatocytes in response to cytokines …