Novel synthetic routes to prepare biologically active quinoxalines and their derivatives: A synthetic review for the last two decades

H Khatoon, E Abdulmalek - Molecules, 2021 - mdpi.com
Quinoxalines, a class of N-heterocyclic compounds, are important biological agents, and a
significant amount of research activity has been directed towards this class. They have …

[HTML][HTML] 2, 3-Dichloroquinoxaline as a versatile building block for heteroaromatic nucleophilic substitution: A review of the last decade

JM Neri, LN Cavalcanti, RM Araujo… - Arabian Journal of …, 2020 - Elsevier
Nucleophilic aromatic substitution (SNAr) is a class of reaction that has become very
important over time. This type of transformation usually proceeds without the use of metal …

Design and synthesis of new quinoxaline derivatives as anticancer agents and apoptotic inducers

AMS El Newahie, YM Nissan, NSM Ismail… - Molecules, 2019 - mdpi.com
The quinoxaline scaffold is a promising platform for the discovery of active chemotherapeutic
agents. Three series of quinoxaline derivatives were synthesized and biologically evaluated …

Synthesis and molecular docking study of new thiazole derivatives as potential tubulin polymerization inhibitors

AO El-Abd, SM Bayomi, AK El-Damasy, B Mansour… - ACS …, 2022 - ACS Publications
A new series of 2, 4-disubstituted thiazole derivatives containing 4-(3, 4, 5-trimethoxyphenyl)
moiety was synthesized and evaluated for their potential anticancer activity as tubulin …

A highly practical and convenient halogenation of fused heterocyclic N-oxides

D Wang, Y Wang, J Zhao, L Li, L Miao, H Sun, P Yu - Tetrahedron, 2016 - Elsevier
A novel, simple and practical method for the regioselective halogenation of fused
heterocyclic N-oxides has been developed. It employs Vilsmeier reagent, generated in situ …

New thiazole derivative as a potential anticancer and topoisomerase II inhibitor

MI Shosha, FZ El-Ablack, EA Saad - Scientific Reports, 2025 - nature.com
To shed light on the significance of thiazole derivatives in the advancement of cancer
medication and to contribute to therapeutic innovation, we have designed the synthesis and …

Design and synthesis of novel main protease inhibitors of COVID-19: quinoxalino [2, 1-b] quinazolin-12-ones

A Tirehdast, S Sheikhi-Mohammareh… - RSC …, 2024 - pubs.rsc.org
The COVID-19 pandemic represents a substantial global challenge, being a significant
cause of mortality in numerous countries. Thus, it is imperative to conduct research to …

Efficient synthesis of 2-phenyl-3-substituted furo/thieno [2, 3-b] quinoxalines via Sonogashira coupling reaction followed by iodocyclization and subsequent palladium …

T Besharati-Seidani, A Keivanloo, B Kaboudin… - RSC …, 2016 - pubs.rsc.org
In this paper, we report the successful synthesis of new 2-phenyl-3-substituted furo/thieno [2,
3-b] quinoxaline derivatives from 2-chloro-3-methoxyquinoxaline and 2-chloro-3 …

Facile synthesis and biological assays of novel 2, 4-disubstituted hydrazinyl-thiazoles analogs

F Ghanbari Pirbasti, NO Mahmoodi - Molecular diversity, 2016 - Springer
A convenient, one-pot multi-component synthesis of new 2, 4-disubstituted hydrazinyl-
thiazoles was accomplished using different aldehydes/ketones, thiosemicarbazide, and 4 …

A One‐pot Facile Synthesis of 2, 3‐Dihydroxyquinoxaline and 2, 3‐Dichloroquinoxaline Derivatives Using Silica Gel as an Efficient Catalyst

PM Zhang, YW Li, J Zhou, LL Gan… - Journal of …, 2018 - Wiley Online Library
An efficient one‐pot reaction has been developed for the synthesis of 2, 3‐
dichloroquinoxaline derivatives 3a–n. The reaction was performed in two steps via a silica …