Emerging experimental and human evidence has linked altered hepatic cholesterol
homeostasis and free cholesterol (FC) accumulation to the pathogenesis of non-alcoholic …

Statins are the gold-standard treatment for the prevention of primary and secondary
cardiovascular disease, which is the leading cause of mortality worldwide. Despite the safety …

Background and aims Meta-analyses of randomized control trials investigating the
association between incident diabetes and statin use showed an increased risk of new …

New-onset diabetes has been observed in clinical trials and meta-analyses involving statin
therapy. To explain this association, three major mechanisms have been proposed and …

Objectives: This study sought to evaluate the effect of intensive and moderate statin therapy
on epicardial adipose tissue (EAT). Background: EAT has been associated with coronary …

A healthy adipose tissue (AT) is indispensable to human wellbeing. Among other roles, it
contributes to energy homeostasis and provides insulation for internal organs. Adipocytes …

Non-alcoholic fatty liver disease (NAFLD) is the major public health challenge for
hepatologists in the twenty-first century. NAFLD comprises a histological spectrum ranging …

Metabolic syndrome has been described as the association of insulin resistance,
hypertension, hyperlipidemia and obesity. Its prevalence increased dramatically, mainly in …

Statins are a class of drugs widely used worldwide to manage hypercholesterolemia and the
prevention of secondary heart attacks. Currently, available statins vary in terms of their …

Adiponectin is secreted by the adipose tissue and it has been shown to be down‐regulated
in states of insulin resistance and in cardiovascular disease. It has also been found to be …