Loss of normal kidney function affects more than 10% of the population and contributes to
morbidity and mortality. Kidney diseases are currently treated with immunosuppressive …

Renal fibrosis is the final pathological process common to any ongoing, chronic kidney
injury or maladaptive repair. It is considered as the underlying pathological process of …

Diabetic kidney disease (DKD) remains a leading cause of new-onset end-stage renal
disease (ESRD), and yet, at present, the treatment is still very limited. A better understanding …

Diabetic nephropathy is a major cause of ESRD worldwide. Despite its prevalence, a lack of
reliable animal models that mimic human disease has delayed the identification of specific …

Diabetic kidney disease, commonly termed diabetic nephropathy (DN), is the most common
cause of end-stage kidney disease (ESKD) worldwide. The characteristic histopathology of …

Mice provide an experimental model of unparalleled flexibility for studying mammalian
diseases. Inbred strains of mice exhibit substantial differences in their susceptibility to the …

Nitric oxide is a versatile molecule, with its actions ranging from haemodynamic regulation to
anti‐proliferative effects on vascular smooth muscle cells. Nitric oxide is produced by the …

Progression of diabetic nephropathy to end-stage kidney disease is mediated by a host of
pro-cesses, but none is as important as the gradual, inexorable scarring of the renal …

Functionally significant polymorphisms in endothelial nitric oxide synthase (eNOS) and
reduced vascular eNOS activity have been associated with increased human diabetic …

В книге представлены современные данные об этиологии и механизмах развития
артериальной гипертензии при сахарном диабете типа 1 и типа 2, о роли …