Kirsten rat sarcoma viral oncogene homolog (KRAS) is a proto-oncogene of the RAS-MAPK
pathway. KRAS mutations are present in a variety of malignancies including lung, colorectal …

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers due to its
aggressiveness and the challenges for early diagnosis and treatment. Recently …

Abstract Tumor-associated macrophages (TAMs), as a major and essential component of
tumor microenvironment (TME), play a critical role in orchestrating pancreatic cancer (PaC) …

Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer. It
has a poor response to conventional therapy and has an extremely poor 5-year survival rate …

The YAP–TEAD protein–protein interaction mediates YAP oncogenic functions downstream
of the Hippo pathway. To date, available YAP–TEAD pharmacologic agents bind into the …

We summarize the most important advances in RNA delivery and nanomedicine. We
describe lipid nanoparticle-based RNA therapeutics and the impacts on the development of …

Pancreatic cancer is fast becoming a global menace and it is projected to be the second
leading cause of cancer-related death by 2030. Pancreatic adenocarcinomas, which …

Aberrant ubiquitin-proteasome system (UPS) contributes to tumorigeneisis or drug
resistance of Pancreatic Adenocarcinoma (PAAD). Previous studies have implicated the …

Obesity is a prominent health issue worldwide and directly impacts pancreatic health, with
obese individuals exhibiting a significant risk for increasing pancreatic ductal …

Individuals diagnosed with cancer often turn to the use of herbal remedies with the intention
of treating and ameliorating the condition, impeding the progression of metastasis …