After decades of directed research, no effective regenerative therapy is currently available to
repair the injured human heart. The epicardium, a layer of mesothelial tissue that envelops …

Abstract The Cre–LoxP system provides a widely used method for studying gene
requirements in the mouse as the main mammalian genetic model organism. To define the …

Diabetes mellitus is characterised by hyperglycaemia, which results from an absolute or
relative lack of insulin. Chronic and acute hyperglycaemia are associated with a range of …

Leydig cells (LCs) are the major androgen-producing cells in the testis. They arise from
steroidogenic progenitors (SPs), whose origins, maintenance, and differentiation dynamics …

In vivo delivery of genome-modifying enzymes holds significant promise for therapeutic
applications and functional genetic screening. Delivery to endogenous tissue stem cells …

Since the late 70s, the continuous pharmaceuticalsinput into the environment has raised
concerns regarding the eventual risk posed by such compounds to human and …

Inducible Cre-dependent systems are frequently used to produce both conditional knockouts
and transgenic mice with regulated expression of the gene of interest. Induction can be …

Abstract Background Tamoxifen-inducible Cre/lox site-specific recombination technology
has been widely used to generate conditional transgenic mice. As an estrogen receptor …

Tissue engineered vascular grafts hold promise for the creation of functional blood vessels
from biodegradable scaffolds. Because the precise mechanisms regulating this process are …

Macrophages are vital to the physiological function of most tissues, but also contribute to
disease through a multitude of pathological roles. They are thus highly plastic and …