Recent advances in technology have led to the realization that the populations of naive T
cells specific for different foreign peptide: MHC (p: MHC) ligands vary in size. This variability …

The cytometric enumeration and characterization of antigen‐specific lymphocytes, as
introduced about 15 years ago, has contributed significantly to our understanding of …

The ability to decode antigen specificities encapsulated in the sequences of rearranged T-
cell receptor (TCR) genes is critical for our understanding of the adaptive immune system …

An individual's T cell repertoire dynamically encodes their pathogen exposure history. To
determine whether pathogen exposure signatures can be identified by documenting public T …

T-cells have to recognize peptides presented on MHC molecules to be activated and elicit
their effector functions. Several studies demonstrate that some peptides are more …

It has long been thought that clonal deletion efficiently removes almost all self-specific T
cells from the peripheral repertoire. We found that self-peptide MHC-specific CD8+ T cells in …

High-throughput T cell receptor (TCR) sequencing allows the characterization of an
individual's TCR repertoire and directly queries their immune state. However, it remains a …

Repetitive pathogen exposure leads to the dominant outgrowth of T cell clones with high T
cell receptor (TCR) affinity to the relevant pathogen-associated antigens. However, low …

Disruption of splicing patterns due to mutations of genes coding splicing factors in tumors
represents a potential source of tumor neoantigens, which would be both public (shared …

Mucosal-associated invariant T cells (MAITs) have potent antimicrobial activity and are
abundant in humans (5%–10% in blood). Despite strong evolutionary conservation of the …