Germline mutation in either BRCA1 or BRCA2 is associated with an increased risk of
ovarian cancer, particularly the most common invasive histotype—serous carcinoma. In …

Traditionally, γ-aminobutyric acid (GABA) is best known for its role as a primary inhibitory
neurotransmitter reducing neuronal excitability in the mammalian central nervous system …

Purpose: The study aim to identify novel molecular subtypes of ovarian cancer by gene
expression profiling with linkage to clinical and pathologic features. Experimental Design …

Purpose Traditional genetic approaches to identify gene mutations in cancer are expensive
and laborious. Nonetheless, if we are to avoid rejecting effective molecular targeted …

Chronic diseases account for approximately 45% of all deaths in developed countries and
are particularly prevalent in countries with the most sophisticated and robust public health …

Purpose: Advanced-stage epithelial ovarian cancer has a poor prognosis with long-term
survival in less than 30% of patients. When the disease is detected in stage I, more than …

Despite advances in therapy, ovarian cancer remains the most deadly of the gynecological
cancers. Less than 30% of women with advanced stage disease survive long‐term. When …

At the cellular level, the biological processes of cell proliferation, growth arrest,
differentiation and apoptosis are all tightly coupled to appropriate alterations in metabolic …

Purpose: Epithelial ovarian cancers are thought to arise from flattened epithelial cells that
cover the ovarian surface or that line inclusion cysts. During malignant transformation …

β‐catenin is the major effector of the canonical Wnt signaling pathway. Mutations in
components of the pathway that stabilize β‐catenin result in augmented gene transcription …