Optimized quantitative mapping of cardiopulmonary oscillations using hyperpolarized 129Xe gas exchange MRI: Digital phantoms and clinical evaluation in CTEPH

J Lu, F Alenezi, E Bier, S Leewiwatwong… - Magnetic …, 2024 - Wiley Online Library
Abstract Purpose The interaction between 129Xe atoms and pulmonary capillary red blood
cells provides cardiogenic signal oscillations that display sensitivity to precapillary and …

Measurement of pulmonary hematocrit using oscillation of hyperpolarized 129Xe MR signals in blood

X Liu, H Li, H Li, M Zhang, Y Zheng… - Magnetic …, 2024 - Wiley Online Library
Purpose To demonstrate the feasibility of measuring pulmonary hematocrit (Hct) in blood in
vivo using oscillation of hyperpolarized 129Xe MR signals and its potential for disease …

Mapping the amplitude and phase of dissolved 129Xe red blood cell signal oscillations with keyhole spectroscopic lung imaging

JH Pilgrim‐Morris, GJ Collier… - Magnetic …, 2025 - Wiley Online Library
Purpose To assess the regional amplitude and phase of dissolved 129Xe red blood cell
(RBC) signal oscillations in the lung vasculature with keyhole spectroscopic imaging and to …

Age, sex, and lung volume dependence of dissolved xenon‐129 MRI gas exchange metrics

GJ Collier, LJ Smith, LC Saunders… - Magnetic …, 2024 - Wiley Online Library
Purpose To characterize the dependence of Xe‐MRI gas transfer metrics upon age, sex, and
lung volume in a group of healthy volunteers. Methods Sixty‐five subjects with no history of …

Loss of pulmonary capillaries in idiopathic pulmonary arterial hypertension with low diffusion capacity is accompanied by early diffuse emphysema detected by 129Xe …

AL Kern, DH Park, J Fuge, JM Hohlfeld, F Wacker… - European …, 2024 - Springer
Objectives Recent studies suggest the existence of an idiopathic pulmonary arterial
hypertension (IPAH) phenotype affecting mostly patients with a smoking history …

Hyperpolarized 129Xe MRI and spectroscopy of gas exchange abnormalities in chronic hypersensitivity pneumonitis

MK Wulfeck, DG Mummy, S Zhang, D Kadi, S Goins… - Respiratory …, 2024 - Elsevier
Purpose To evaluate 3D gas-exchange functional imaging characteristics using 129 Xe MRI
in a group of study participants with chronic hypersensitivity pneumonitis (CHP) as …

Functional gas exchange measures on 129Xe MRI and spectroscopy are associated with age, sex, and BMI in healthy subjects

D Mummy, S Zhang, A Bechtel, J Lu… - Frontiers in …, 2024 - frontiersin.org
Introduction Hyperpolarized 129Xe MRI and spectroscopy is a rapidly growing technique for
assessing lung function, with applications in a wide range of obstructive, restrictive, and …

[HTML][HTML] Hyperpolarized 129Xe MRI and Spectroscopy of Gas-Exchange Abnormalities in Bilateral Lung Transplant Recipients

A Simmons, D Mummy, S Zhang, S Leewiwatwong… - JHLT Open, 2024 - Elsevier
BACKGROUND There is currently no sensitive, non-invasive method of screening for
chronic lung allograft dysfunction (CLAD), the primary barrier to long-term survival after lung …