Hypertension is a major cardiovascular disease risk factor and contributor to premature
death globally. Family-based investigations confirmed a significant heritable component of …

Sepsis is caused by an overwhelming immune response to bacterial infection. The discovery
of high mobility group box 1 (HMGB1) as a late mediator of lethal sepsis has prompted …

Classical inbred mouse strains have historically been instrumental in mapping
immunological traits. However, most of the classical strains originate from a relatively limited …

Background Oysters have important ecological functions in their natural environment, acting
as global carbon sinks and improving water quality by removing excess nutrients from the …

Estrogen receptor–negative (ER-negative) breast cancer is thought to be more malignant
and devastating than ER-positive breast cancer. ER-negative breast cancer exhibits …

Prostanoids and PGE2 in particular have been long viewed as one of the major mediators of
inflammation in arthritis. However, experimental data indicate that PGE2 can serve both pro …

Muller cells play a prominent role in inflammatory conditions of the retina. They are part of
the retinal innate immune response. The endocannabinoid system functions as an immune …

Background We have previously demonstrated a Toll-like receptor (TLR)-mediated hyper-
responsive phenotype in our cohort of localized aggressive periodontitis (LAP) individuals …

Recognition of microbial components is critical for activation of TLRs, subsequent innate
immune signaling, and directing adaptive immune responses. The DNA sensor TLR9 traffics …

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy
worldwide. Somatic copy number alterations (CNAs) play a significant role in the …