DNA is traditionally known as a central genetic biomolecule in living systems. From an
alternative perspective, DNA is a versatile molecular building-block for the construction of …

Nearly 50 years since its potential as a fluorescent base analogue was first recognized, 2-
aminopurine (2AP) continues to be the most widely used fluorescent probe of DNA structure …

Förster resonance energy transfer (FRET) is a powerful tool for monitoring molecular
distances and interactions at the nanoscale level. The strong dependence of transfer …

For the first time, three 2-input elementary AND, OR, INHIBIT logic gates have been
constructed by using CRISPR-Cas12a system. These logic gates utilised the intrinsic …

The design of new protein structures is challenging due to their vast sequence space and
the complexity of protein folding. Here, we report a new modular DNA-templated strategy to …

An increasing number of human disorders are attributed to genomic expansions of short
tandem repeats (STRs). Secondary DNA structures formed by STRs are believed to play an …

The explosive growth of single-molecule techniques is transforming our understanding of
biology, helping to develop new physics inspired by emergent biological processes, and …

A water-soluble self-assembled supramolecular FeII4L4 tetrahedron binds to single
stranded DNA, mismatched DNA base pairs, and three-way DNA junctions. Binding of the …

Nucleic acid fluorescent probes are playing increasingly important roles in biological
sensing in recent years. In addition to the conventional functions of single-stranded …

Expansions of CAG/CTG trinucleotide repeats in DNA are the cause of at least 17
degenerative human disorders, including Huntington's Disease. Repeat instability is thought …