Comprehensive Summary Cyclobutane derivatives have been recognized as useful
structural motifs in organic synthesis and drug design. With the revival of photochemistry, the …

The development of two divergent and complementary Lewis acid catalyzed additions of
bicyclobutanes to imines is described. Microscale high‐throughput experimentation was …

Ring-opening of bicyclo [1.1. 0] butanes (BCBs) is emerging as a powerful strategy for 1, 3-
difunctionalized cyclobutane synthesis. However, reported radical strain-release reactions …

Ligand-controlled reactivity plays an important role in transition-metal catalysis, enabling a
vast number of efficient transformations to be discovered and developed. However, a single …

Chain walking has been an efficient route to realize the functionalization of inert C (sp3)− H
bonds, but this strategy is limited to mono‐olefin migration and functionalization. Herein, we …

Catalytic enantioselective functionalization of cyclobutenes constitutes a general and
modular strategy for construction of enantioenriched complex cyclobutanes bearing multiple …

Although ring-opening reactions of bicyclobutanes bearing electron-withdrawing groups,
typically with β-selectivity, have evolved as a powerful platform for synthesis of cyclobutanes …

Abstract Electronically matched nucleophilic 1, 6‐conjugate addition has been well studied
and widely applied in synthetic areas. In contrast, nucleophilic 1, 5‐conjugate addition …

Four‐membered carbocycles are important structural motifs found in several natural
products and drugs. Amongst those, cyclobutenes are attractive intermediates because the …

Four-membered carbocycles are fundamental substructures in bioactive molecules and
approved drugs and serve as irreplaceable building blocks in organic synthesis. However …