Aging is driven by hallmarks fulfilling the following three premises:(1) their age-associated
manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …

Aging is typified by a progressive decline in mitochondrial activity and stress resilience.
Here, we review how mitochondrial stress pathways have pleiotropic effects on cellular and …

The past two centuries have witnessed an unprecedented rise in human life expectancy.
Sustaining longer lives with reduced periods of disability will require an understanding of the …

Mitochondria were first postulated to contribute to aging more than 40 years ago. During the
following decades, multiple lines of evidence in model organisms and humans showed that …

Mitochondria are double‐membrane‐bound organelles that are present in all nucleated
eukaryotic cells and are responsible for the production of cellular energy in the form of ATP …

BACKGROUND There is a great inter-individual variability of ovarian ageing, and almost
20% of patients consulting for infertility show signs of premature ovarian ageing. This …

Many cancers have long been thought to primarily metabolize glucose for energy production—
a phenomenon known as the Warburg Effect, after the classic studies of Otto Warburg in the …

Mitochondrial DNA (mtDNA) mutations are maternally inherited and are associated with a
broad range of debilitating and fatal diseases. Reproductive technologies designed to …

Mitochondrial genomes (mitochondrial DNA, mtDNA) encode essential oxidative
phosphorylation (OXPHOS) components. Because hundreds of mtDNAs exist per cell, a …

Oxidative phosphorylation (OXPHOS) defects caused by somatic mitochondrial DNA
mutations increase with age in human colorectal epithelium and are prevalent in colorectal …