Rationale: Glycolytic shift is implicated in the pathogenesis of pulmonary arterial
hypertension (PAH). It remains unknown how glycolysis is increased and how increased …

Embryonic development repeatedly deploys a finite number of signaling pathways to control
a multitude of processes such as patterning, growth and differentiation. Diversity in gene …

Calpain mediates collagen synthesis and cell proliferation and plays an important role in
pulmonary vascular remodeling in pulmonary arterial hypertension (PAH). In the present …

Calpain is a conserved family of calcium-dependent, cytosolic, neutral cysteine proteases.
The best characterized members of the family are the ubiquitously expressed calpain 1 and …

Calpains are a family of intracellular proteases defined by a conserved protease domain. In
the marine mollusk Aplysia californica, calpains are important for the induction of long-term …

Echinoderms, as invertebrate deuterostomes, have amazing neuronal intrinsic growth
aptitude triggered at any time point during the animal lifespan leading to successful …

Background Calpains are calcium regulated intracellular cysteine proteases implicated in a
variety of physiological functions and pathological conditions. The Drosophila melanogaster …

Persistent enzymatic activity has been proposed as a possible mechanism for maintenance
of long-lasting memory. The main candidate enzymes for long-term memory maintenance …

Patients who undergo aHSCT are at high risk of EBV and CMV infections due to immune-
suppression and the lack of anti-viral cellular immune responses in the post-transplant …

The nervous system of an organism is exceedingly complex and yet highly specific in the
connections that it makes. The mechanisms by which a functional nervous system is …