Apoptosis is a major form of cell death, characterized initially by a series of stereotypic
morphological changes. In the nematode Caenorhabditis elegans, the gene ced-3 encodes …

▪ Abstract Apoptosis is a genetically programmed, morphologically distinct form of cell death
that can be triggered by a variety of physiological and pathological stimuli. Studies …

Abstract Interleukin-1β (IL-1β)-converting enzyme cleaves the IL-1β precursor to mature IL-
1β, an important mediator of inflammation. The identification of the enzyme as a unique …

The interleukin-1β (IL-1β) converting enzyme (ICE) processes the inactive IL-1β precursor to
the proinflammatory cytokine. Adherent monocytes from mice harboring a disrupted ICE …

Apoptosis is a morphologically distinct form of programmed cell death that plays a major role
during development, homeostasis, and in many diseases including cancer, acquired …

IL-1β-converting enzyme (ICE) cleaves pro-1L-1β to generate mature IL-1β. ICE is
homologous to other proteins that have been implicated in apoptosis, including CED-3 and …

Interleukin-1β (IL-1β) mediates a wide range of immune and inflammatory responses. The
active cytokine is generated by proteolytic cleavage of an inactive precursor. A …

The death morphology commonly known as apoptosis results from a post-translational
pathway driven largely by specific limited proteolysis. In the last decade the structural basis …

Caspases are a large family of evolutionarily conserved proteases found from
Caenorhabditis elegans to humans. Although the first caspase was identified as a …

The caspase family represents a new class of intracellular cysteine proteases with known or
suspected roles in cytokine maturation and apoptosis. These enzymes display a preference …