Propargylamines are a versatile class of compounds which find broad application in many
fields of chemistry. This review aims to describe the different strategies developed so far for …

Chiral molecules containing asymmetric carbon centers bonded with nitrogen are ubiquitous
in nature and also form important structural fragments in both natural and man-made …

Over the past decade, large strides have been achieved in the invention of methods for the
direct enantioselective addition of alkynes and metal alkynylide nucleophiles into prochiral …

A proper copper catalyst with a chiral pyridine-2, 6-bisoxazoline (pybox) ligand was used to
convert a variety of propargylic acetates with different side chains (R= Ar, Bn, Alkyl) into their …

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A Cu (I)-catalyzed direct addition of alkynes to imines was developed. The process is simple
and provides a diverse range of propargylamines in high enantiomeric excess and good …

Desymmetrization of meso compounds to yield chiral products proved to be a powerful
synthetic tool in asymmetric synthesis since it allows formation of multiple stereogenic …

A copper (I) complex of i-Pr-pybox-diPh has been found to be an efficient catalyst for an
enantioselective one-pot three-component synthesis of propargylamines from aldehydes …

We have shown that Me-DuPHOS monoxide (BozPHOS) is a very effective ligand in the
copper-catalyzed addition of dialkylzinc to N-phosphinoylimines providing access to α-chiral …

An efficient catalytic and enantioselective method (up to> 98% ee) for Mannich reactions
between trimethylsilyl enol ethers derived from acetone and acetophenone and aryl, alkenyl …