The pathophysiological roles and the therapeutic potentials of Myc family are reviewed in
this article. The physiological functions and molecular machineries in stem cells, including …

Enhanced and deregulated expression of N-MYC, a member of the MYC family of
transcription factors, drives the development of multiple tumors, including tumors of the …

The HER-2/neu oncogene is a member of the erb B-like oncogene family, and is related to,
but distinct from, the epidermal growth factor receptor. This gene has been shown to be …

Despite recent therapeutic advances, prostate cancer remains a leading cause of cancer-
related death. A subset of castration-resistant prostate cancers become androgen receptor …

A gene, termed gli, was identified that is amplified more than 50-fold in a malignant glioma.
The gene is expressed at high levels in the original tumor and its derived cell line and is …

The search for genetic damage in neoplastic cells now occupies a central place in cancer
research. Diverse examples of such damage are in hand, and they in turn hint at …

Primary malignant gliomas from 63 patients were analyzed to determine the relationship
between amplification of the gene encoding the epidermal growth factor receptor (EGFR) …

To define the role of cellular oncogenes in human cancers, we studied the prevalence of
mutational activation of ras oncogenes in untreated non-small-cell lung cancer. Genomic …

We are exploring the origin and function of amplified DNA sequences associated with
double minutes (DMs) in a spontaneously transformed derivative of mouse 3T3 cells …

Until the early 1960s, cancer treatment consisted primarily of surgery and radiation therapy.
Most practitioners then viewed the treatment of terminally ill cancer patients with heroic …