Matrix metalloproteinases (MMPs) are a family of zinc-dependent extracellular matrix (ECM)
remodeling endopeptidases that have the capacity to degrade almost every component of …

The extracellular matrix (ECM) is a network of different proteins and proteoglycans that
controls differentiation, migration, repair, survival, and development, and it seems that its …

Fibrosis in adipose tissue is a major driver of obesity-related metabolic dysregulation. It is
characterized by an overaccumulation of extracellular matrix (ECM) during unhealthy …

Obesity and type 2 diabetes are causally related, yet there is considerable heterogeneity in
the consequences of both conditions and the mechanisms of action are poorly defined. Here …

At the simplest level, obesity is the manifestation of an imbalance between caloric intake and
expenditure; however, the pathophysiological mechanisms that govern the development of …

Obesity and type 2 diabetes are prevalent chronic diseases effectively managed by
semaglutide. Here we studied the effects of semaglutide on the circulating proteome using …

Cancer is one of the leading causes of death in patients worldwide, where invasion and
metastasis are directly responsible for this statement. Although cancer therapy has …

Abstract Proximity Extension Assay (PEA) and mass spectrometry (MS) methodologies were
utilized for the proteomic and lipidomic characterization of plasma specimens from patients …

Many individuals infected with the severe acute respiratory syndrome coronavirus-2 (SARS-
CoV-2) develop no or only mild symptoms, but some can go on onto develop a spectrum of …

Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are
pivotal regulators of extracellular matrix (ECM) composition and could, due to their dynamic …