Protocadherins (Pcdhs) are cell adhesion molecules that belong to the cadherin
superfamily, and are subdivided into clustered (cPcdhs) and non-clustered Pcdhs (ncPcdhs) …

Mammalian neurons lose the ability to regenerate their central nervous system axons as
they mature during embryonic or early postnatal development. Neuronal maturation requires …

Injuries to the adult CNS often result in permanent disabilities because neurons lose the
ability to regenerate their axon during development. Here, whole transcriptome sequencing …

The majority of vertebrate protocadherin (Pcdh) genes are clustered in a single genomic
locus, and this remarkable genomic organization is highly conserved from teleosts to …

Self-avoidance, the tendency of neurites of the same cell to selectively avoid each other, is a
property of both vertebrate and invertebrate neurons. In Drosophila, self-avoidance is …

The protocadherins (Pcdhs), which make up the most diverse group within the cadherin
superfamily, were first discovered in the early 1990s. Data implicating the Pcdhs, including …

Growth of a properly complex dendrite arbor is a key step in neuronal differentiation and a
prerequisite for neural circuit formation. Diverse cell surface molecules, such as the …

Clustered protocadherin proteins (α-, β-, and γ-Pcdhs) provide a high level of cell-surface
diversity to individual vertebrate neurons, engaging in highly specific homophilic interactions …

Light touch sensation begins with activation of low-threshold mechanoreceptor (LTMR)
endings in the skin and propagation of their signals to the spinal cord and brainstem. We …

The establishment of a functional cerebral cortex depends on the proper execution of
multiple developmental steps, culminating in dendritic and axonal outgrowth and the …