Evolutionary conservation and experimental tractability have made animal model systems
invaluable tools in our quest to understand human embryogenesis, both normal and …

The mammalian neocortex is a highly organized six-layered structure with four major cortical
neuron subtypes: corticothalamic projection neurons (CThPNs), subcerebral projection …

The hypothalamus is a region of the brain that plays an important role in regulating body
functions and behaviors. There is a growing interest in human pluripotent stem cells …

The transcription factor FOXG1 serves pleiotropic functions in brain development ranging
from the regulation of precursor proliferation to the control of cortical circuit formation. Loss …

The transcription factor Foxg1 is known to be continuously expressed at a high level in
mature neurons in the telencephalon, but little is known about its role in neural plasticity …

FOXG1 (forkhead box G1) syndrome is a neurodevelopmental disorder caused by variants
in the Foxg1 gene that affect brain structure and function. Individuals affected by FOXG1 …

FOXG1 syndrome is a severe encephalopathy that exhibit intellectual disability, emotional
disorder, and limited social communication. To elucidate the contribution of somatostatin …

The Wnt signaling pathway plays key roles in various developmental processes. Wnt5a,
which activates the non-canonical pathway, has been shown to be particularly important for …

The Forkhead transcription factor FOXG1 is a prerequisite for telencephalon development in
mammals and is an essential factor controlling expansion of the dorsal telencephalon by …

The vertebrate telencephalic lobes consist of the pallium (dorsal) and subpallium (ventral).
The subpallium gives rise to the basal ganglia, encompassing the pallidum and striatum …