Human diseases have been a critical threat from the beginning of human history. Knowing
the origin, course of action and treatment of any disease state is essential. A microscopic …

Since the discovery and classification of non-coding RNAs, their roles have gained great
attention. In this respect, microRNAs and long non-coding RNAs have been firmly …

It is now widely recognised that the environment in space activates a diverse set of genes
involved in regulating fundamental cellular pathways. This includes the activation of genes …

Sickle cell disease (SCD) is one of the most common inherited hemoglobinopathy disorders
that affects millions of people worldwide. Reactivation of HBG (HBG1, HBG2) gene …

Inherited genetic modifiers and pharmacologic agents that enhance fetal hemoglobin (HbF)
expression reverse the clinical severity of sickle cell disease (SCD). Recent efforts to …

Background: RNA viruses and especially coronaviruses could act inside host cells not only
by building their own proteins, but also by perturbing the cell metabolism. We show the …

Background: The adventure of the mRNA vaccine began thirty years ago in the context of
influenza. This consisted in encapsulating the mRNA coding for a viral protein in a lipid …

Background Hydroxyurea is one of the earliest drugs that showed promise in the
management of haemoglobinopathies that include β-thalassaemia and sickle cell disease …

Background and Objectives: Sickle cell disorder (SCD) is a paradigmatic example of a
complex monogenic disorder. SCD is characterized by the production of abnormal …

In humans, fetal erythropoiesis takes place in the liver whereas adult erythropoiesis occurs
in the bone marrow. Fetal and adult erythroid cells are not only produced at different sites …