The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide
range of incurable diseases. Recent rapid advances in biotechnology and molecular …

Vaccinology is shifting toward synthetic RNA platforms which allow for rapid, scalable, and
cell-free manufacturing of prophylactic and therapeutic vaccines. The simple development …

In the last two decades, there has been growing interest in mRNA-based technology for the
development of prophylactic vaccines against infectious diseases. Technological …

This review will explore the four major pillars required for design and development of an
saRNA vaccine: Antigen design, vector design, non-viral delivery systems, and …

The recent approval of messenger RNA (mRNA)-based vaccines to combat the SARS-CoV-
2 pandemic highlights the potential of both conventional mRNA and self-amplifying mRNA …

Here, we present a potent RNA vaccine approach based on a novel bipartite vector system
using trans-amplifying RNA (taRNA). The vector cassette encoding the vaccine antigen …

In the prevention and treatment of infectious diseases, mRNA vaccines hold great promise
because of their low risk of insertional mutagenesis, high potency, accelerated development …

The accelerated progress and approval of two mRNA-based vaccines to address the SARS-
CoV-2 virus were unprecedented. This record-setting feat was made possible through the …

Introduction Cancer immunotherapy is more dependent on monoclonal antibodies, proteins,
and cells, as therapeutic agents, to attain prominent outcomes. However, cancer …

The present use of mRNA vaccines against COVID-19 has shown for the first time the
potential of mRNA vaccines for infectious diseases. Here we will summarize the current …