Photochemical and electrochemical applications of proton-coupled electron transfer in organic synthesis
We present here a review of the photochemical and electrochemical applications of multi-
site proton-coupled electron transfer (MS-PCET) in organic synthesis. MS-PCETs are redox …
site proton-coupled electron transfer (MS-PCET) in organic synthesis. MS-PCETs are redox …
The expanding role of prodrugs in contemporary drug design and development
J Rautio, NA Meanwell, L Di… - Nature reviews drug …, 2018 - nature.com
Prodrugs are molecules with little or no pharmacological activity that are converted to the
active parent drug in vivo by enzymatic or chemical reactions or by a combination of the two …
active parent drug in vivo by enzymatic or chemical reactions or by a combination of the two …
Benzothiazole derivatives as anticancer agents
Benzothiazole (BTA) belongs to the heterocyclic class of bicyclic compounds. BTA
derivatives possesses broad spectrum biological activities such as anticancer, antioxidant …
derivatives possesses broad spectrum biological activities such as anticancer, antioxidant …
A comprehensive review in current developments of benzothiazole-based molecules in medicinal chemistry
Benzothiazole (BTA) and its derivatives are the most important heterocyclic compounds,
which are common and integral feature of a variety of natural products and pharmaceutical …
which are common and integral feature of a variety of natural products and pharmaceutical …
Rational approaches, design strategies, structure activity relationship and mechanistic insights for anticancer hybrids
A Hybrid drug which comprises the incorporation of two drug pharmacophores in one single
molecule are basically designed to interact with multiple targets or to amplify its effect …
molecule are basically designed to interact with multiple targets or to amplify its effect …
External oxidant-free oxidative cross-coupling: a photoredox cobalt-catalyzed aromatic C–H thiolation for constructing C–S bonds
An external oxidant-free oxidative coupling for aromatic C–H thiolation by visible-light
photoredox cobalt-catalysis has been developed. Various substrates could afford …
photoredox cobalt-catalysis has been developed. Various substrates could afford …
Recent Advances in Catalytic C(sp2)–H Allylation Reactions
The linear or branched allyl moieties on aromatic rings are well-known as ubiquitous
structural motifs found in a range of natural products and medicinally relevant molecules …
structural motifs found in a range of natural products and medicinally relevant molecules …
The role of fluorine in medicinal chemistry
P Shah, AD Westwell - Journal of enzyme inhibition and medicinal …, 2007 - Taylor & Francis
The small and highly electronegative fluorine atom can play a remarkable role in medicinal
chemistry. Selective installation of fluorine into a therapeutic or diagnostic small molecule …
chemistry. Selective installation of fluorine into a therapeutic or diagnostic small molecule …
Copper nanoparticles as inexpensive and efficient catalyst: A valuable contribution in organic synthesis
NK Ojha, GV Zyryanov, A Majee, VN Charushin… - Coordination Chemistry …, 2017 - Elsevier
Copper nanoparticles have been explored as a new class of heterogeneous catalyst in
various chemical transformations. This review surveys the most useful organic …
various chemical transformations. This review surveys the most useful organic …
A decade update on solvent and catalyst-free neat organic reactions: a step forward towards sustainability
Particular success has been achieved in the synthesis of new products and in processes
since the twelve principles of “green chemistry” were formulated in the 1990s. These …
since the twelve principles of “green chemistry” were formulated in the 1990s. These …