The Hierarchical Taxonomy of Psychopathology (HiTOP) is a quantitative nosological
system that addresses shortcomings of traditional mental disorder diagnoses, including …

BACKGROUND: Nociplastic pain has been recently introduced as a third mechanistic
descriptor of pain arising primarily from alterations of neural processing, in contrast to pain …

Early-life adversities are associated with altered defensive responses. Here, we
demonstrate that the repeated cross-fostering (RCF) paradigm of early maternal separation …

Neuropathic pain (NeuP) is an important clinical problem accompanying negative mood
symptoms. Neuroinflammation in the amygdala is critically involved in NeuP, and the …

The involvement of pro-inflammatory mediators complicates the complex mechanism in
neuropathic pain (NP). This study investigated the roles of bromelain against pro …

Structural neuroimaging studies of individuals with chronic pain conditions have often
observed decreased regional grey matter at a phenotypic level. However, it is not known if …

Frequent and increasing use of over-the-counter analgesics (OTCA) is a public health
concern. Pain conditions and psychological distress are related to frequent OTCA use, and …

Both common pain and anxiety problems are widespread, debilitating and often begin in
childhood-adolescence. Twin studies indicate that this co-occurrence is likely due to shared …

Data on the etiological factors underlying the co-occurrence of common adolescent pain
with anxiety and depression symptoms are very limited. Opioid prescriptions for adolescent …

The opioid crisis' pathways from first exposure onwards to eventual illnesses and fatalities
are multiple, intertwined and difficult to dissect. Here, we offer a multidisciplinary appraisal of …