Copper-containing enzymes perform fundamental functions by activating dioxygen (O 2) and
therefore allowing chemical energy-transfer for aerobic metabolism. The copper …

Endosomes are dynamic intracellular compartments that control the sorting of a constant
stream of different transmembrane cargos either for ESCRT‐mediated degradation or for …

Selenium homeostasis depends on hepatic biosynthesis of selenoprotein P (SELENOP) and
SELENOP-mediated transport from the liver to eg the brain. In addition, the liver maintains …

All known eukaryotes require copper for their development and survival. The essentiality of
copper reflects its widespread use as a co-factor in conserved enzymes that catalyze …

The conserved oligomeric Golgi (COG) complex, a multisubunit tethering complex of the
CATCHR (complexes associated with tethering containing helical rods) family, controls …

How do neurons adapt their endolysosomal system to address the particular challenge of
membrane transport across their elaborate cellular landscape and to maintain proteostasis …

Copper is vital for numerous cellular functions affecting all tissues and organ systems in the
body. The copper pump, ATP7A is critical for whole-body, cellular, and subcellular copper …

Membrane trafficking pathways emanating from the Golgi regulate a wide range of cellular
processes. One of these is the maintenance of copper (Cu) homeostasis operated by the …

Wilson disease (WD) is a rare disorder caused by mutations in ATP7B, which leads to the
defective biliary excretion of copper. The subsequent gradual accumulation of copper in …

Copper (Cu) homeostasis is essential for the development and function of many organisms.
In humans, Cu misbalance causes serious pathologies and has been observed in a growing …