Quinacrine, also known as mepacrine, has originally been used as an antimalarial drug for
close to a century, but was recently rediscovered as an anticancer agent. The mechanisms …

Breast cancer is the most common cancer among women and is considered a developed
country disease. Moreover, is a heterogenous disease, existing different types and stages of …

Oliveria decumbens is an Iranian endemic plant used extensively in traditional medicine.
Recently, some studies have been performed on biological effects of Oliveria essential oil …

With the increasing production and demand of plastic products in life, inescapable bisphenol
A (BPA) exposure results in a threat to the health of organisms. Selenium (Se) is an …

Background Azithromycin is a member of macrolide antibiotics, and has been reported to
inhibit the proliferation of cancer cells. However, the underlying mechanisms are not been …

Chloroquine is a common antimalarial drug and is listed in the World Health Organization
Standard List of Essential Medicines because of its safety, low cost and ease of use. Besides …

There are two well-described thermogenic sites; brown adipose tissue (BAT) and skeletal
muscle, which utilize distinct mechanisms of heat production. In BAT, mitochondrial …

Complete eradication of aggressive oral cancer remains a challenge due to the presence of
CSCs. They resist conventional chemotherapeutic agents due to their self-renewal, drug …

We have previously shown that the anti-malarial compound Quinacrine (QC) inhibits ovarian
cancer (OC) growth by modulating autophagy. In the present study we extended these …

To overcome the toxicity, pharmacokinetics and drug resistance associated with doxorubicin
(DOX), a strategy was developed by encapsulating DOX-loaded-PLGA-PVA-nanoparticles …