Pax6 is a highly conserved transcription factor among vertebrates and is important in various
developmental processes in the central nervous system (CNS), including patterning of the …

Eye development has been a paradigm for the study of organogenesis, from the
demonstration of lens induction through epithelial tissue morphogenesis, to neuronal …

Hydrogen peroxide is considered deleterious molecule that cause cellular damage integrity
and function. Its key redox signaling molecule in oxidative stress and exerts toxicity on a …

The microRNA-183/96/182 cluster is highly expressed in the retina and other sensory
organs. To uncover its in vivo functions in the retina, we generated a knockout mouse model …

Loss of photoreceptors due to retinal degeneration is a major cause of blindness in the
developed world. While no effective treatment is currently available, cell replacement …

Neuronal degenerations in the retina are leading causes of blindness. Like most other areas
of the CNS, the neurons of the mammalian retina are not replaced following degeneration …

The light-damaged zebrafish retina results in the death of photoreceptor cells and the
subsequent regeneration of the missing rod and cone cells. Photoreceptor regeneration …

The epithelial layers of the ciliary body (CB) and iris are non-neural structures that
differentiate from the anterior region of the eyecup, the ciliary margin (CM). We show here …

microRNAs (miRNAs) are endogenous, small, non-coding, regulatory RNAs,∼ 22
nucleotides (nts) in size. Since the first discovery of miRNAs in 1993 in Caenorhabditis …

Retinal stem cells (RSCs) are present in the ciliary margin of the adult human eye and can
give rise to all retinal cell types. Here we show that modulation of retinal transcription factor …