Hyperoside inhibits EHV-8 infection via alleviating oxidative stress and IFN production through activating JNK/Keap1/Nrf2/HO-1 signaling pathways

T Wang, L Hu, R Li, H Ren, S Li, Q Sun, X Ding… - Journal of …, 2024 - Am Soc Microbiol
ABSTRACT Equine herpesvirus type 8 (EHV-8) causes abortion and respiratory disease in
horses and donkeys, leading to serious economic losses in the global equine industry …

[HTML][HTML] Protective role of cepharanthine against equid herpesvirus type 8 through AMPK and Nrf2/HO-1 pathway activation

S Li, L Li, Y Sun, MZ Khan, Y Yu, L Ruan, L Chen… - Viruses, 2024 - mdpi.com
Equid herpesvirus type 8 (EqHV-8) is known to cause respiratory disease and miscarriage in
horses and donkeys, which is a major problem for the equine farming industry. However …

Heme oxygenase-1 is an equid alphaherpesvirus 8 replication restriction host protein and suppresses viral replication via the PKCβ/ERK1/ERK2 and NO/cGMP/PKG …

T Wang, S Li, X Hu, Y Geng, L Chen, W Liu… - Microbiology …, 2024 - Am Soc Microbiol
ABSTRACT Equid alphaherpesvirus 8 (EqHV-8) is one of the most economically important
viruses that is known to cause severe respiratory disease, abortion, and neurological …

Pathogenicity and host cytokines response of EqHV-8 infection in C57BL/6J mice

S Li, C Xi, Y Geng, W Tian, L Li, T Wang, J Zhao - Microbial Pathogenesis, 2024 - Elsevier
Abstract Equid herpesvirus type 8 (EqHV-8) is known to cause abortion, respiratory signs,
and viral encephalitis in equines. EqHV-8 has been reported to cause serious economic …

Rutin prevents EqHV-8 induced infection and oxidative stress via Nrf2/HO-1 signaling pathway

L Chen, S Li, W Li, Y Yu, Q Sun, W Chen… - Frontiers in Cellular …, 2024 - frontiersin.org
Introduction The Nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1)
signaling pathway has been extensively studied for its role in regulating antioxidant and …

Blebbistatin as a novel antiviral agent targeting equid herpesvirus type 8

L Li, X Cui, Y Yu, Q Sun, W Li, Y Li, S Li… - Frontiers in Veterinary …, 2024 - frontiersin.org
Introduction Equid herpesvirus type 8 (EqHV-8) poses a significant threat to equine health,
leading to miscarriages and respiratory diseases in horses and donkeys, and results in …

[HTML][HTML] Equine Herpesvirus-1 Induced Respiratory Disease in Dezhou Donkey Foals: Case Study from China, 2024

L Ruan, L Li, R Yang, A You, MZ Khan, Y Yu… - Veterinary …, 2025 - mdpi.com
Abstract Equine herpesvirus-1 (EHV-1) is a significant pathogen that causes substantial
economic losses in the equine industry worldwide, which leads to severe respiratory …