The placenta sits at the interface between the maternal and fetal vascular beds where it
mediates nutrient and waste exchange to enable in utero existence. Placental cells …

During mouse preimplantation embryo development, totipotent blastomeres generate the
first three cell lineages of the embryo: trophectoderm, epiblast and primitive endoderm. In …

Recent genomic studies challenge the conventional model that each metastasis must arise
from a single tumor cell and instead reveal that metastases can be composed of multiple …

Despite the important role that monozygotic twins have played in genetics research, little is
known about their genomic differences. Here we show that monozygotic twins differ on …

The major and essential objective of pre-implantation development is to establish embryonic
and extra-embryonic cell fates. To address when and how this fundamental process is …

In the transgenic multicolor labeling strategy called'Brainbow', Cre-loxP recombination is
used to create a stochastic choice of expression among fluorescent proteins, resulting in the …

It remains an open question when and how the first cell fate decision is made in mammals.
Using deep single-cell RNA-seq of matched sister blastomeres, we report highly …

To implant in the uterus, the mammalian embryo first specifies two cell lineages: the
pluripotent inner cell mass that forms the fetus, and the outer trophectoderm layer that forms …

Advances in imaging and cell-labeling techniques have greatly enhanced our
understanding of developmental and neurobiological processes. Among vertebrates …

Transcription factor (TF) binding to DNA is fundamental for gene regulation. However, it
remains unknown how the dynamics of TF-DNA interactions change during cell-fate …