Combined targeting of senescent cells and senescent macrophages: a new idea for integrated treatment of lung cancer

M Gu, Y Liu, W Zheng, Z Jing, X Li, W Guo… - Seminars in cancer …, 2024 - Elsevier
Lung cancer is one of the most common cancers worldwide and a leading cause of cancer-
related deaths. Macrophages play a key role in the immune response and the tumour …

The next frontier in immunotherapy: potential and challenges of CAR-macrophages

J Li, P Chen, W Ma - Experimental Hematology & Oncology, 2024 - Springer
Chimeric antigen receptor macrophage (CAR-MΦ) represents a significant advancement in
immunotherapy, especially for treating solid tumors where traditional CAR-T therapies face …

Osteopontin is a therapeutic target that drives breast cancer recurrence

Y Gu, T Taifour, T Bui, D Zuo, A Pacis, A Poirier… - Nature …, 2024 - nature.com
Recurrent breast cancers often develop resistance to standard-of-care therapies. Identifying
targetable factors contributing to cancer recurrence remains the rate-limiting step in …

Mitochondrial regulation in the tumor microenvironment: targeting mitochondria for immunotherapy

M Ahn, A Ali, JH Seo - Frontiers in Immunology, 2024 - frontiersin.org
Mitochondrial regulation plays a crucial role in cancer immunity in the tumor
microenvironment (TME). Infiltrating immune cells, including T cells, natural killer (NK) cells …

Tumor‐associated macrophages: A sentinel of innate immune system in tumor microenvironment gone haywire

S Malik, N Sureka, S Ahuja, D Aden… - Cell Biology …, 2024 - Wiley Online Library
The tumor microenvironment (TME) is a critical determinant in the initiation, progression, and
treatment outcomes of various cancers. Comprising of cancer‐associated fibroblasts (CAF) …

Self-Healing Photothermal Nanotherapeutics for Enhanced Tumor Therapy through Triple Ferroptosis Amplification and Cascade Inflammation Inhibition

Y Zheng, F Zheng, R Xu, X Sun, J Yu… - … Applied Materials & …, 2024 - ACS Publications
The therapeutic effectiveness of photothermal therapy (PTT) is limited by heat tolerance and
PTT-induced inflammation, which increases the risk of tumor metastasis and recurrence …

[HTML][HTML] Application of nanotechnology and phytochemicals in anticancer therapy

JH Kim, BO Dareowolabi, R Thiruvengadam, EY Moon - Pharmaceutics, 2024 - mdpi.com
Cancer is well recognized as a leading cause of mortality. Although surgery tends to be the
primary treatment option for many solid cancers, cancer surgery is still a risk factor for …

Drug resistance and tumor immune microenvironment: An overview of current understandings

Y Liu, J Liang, Y Zhang, Q Guo - … Journal of Oncology, 2024 - spandidos-publications.com
The use of antitumor drugs represents a reliable strategy for cancer therapy. Unfortunately,
drug resistance has become increasingly common and contributes to tumor metastasis and …

[HTML][HTML] Unveiling the dynamic interplay between cancer stem cells and the tumor microenvironment in melanoma: implications for novel therapeutic strategies

P Limonta, R Chiaramonte, L Casati - Cancers, 2024 - mdpi.com
Simple Summary Resistance to standard therapies represents a major challenge in
melanoma treatment. This is mainly related to the high heterogeneity of this malignancy due …

Therapeutic applications of nanomedicine: recent developments and future perspectives

F Rehan, M Zhang, J Fang, K Greish - Molecules, 2024 - mdpi.com
The concept of nanomedicine has evolved significantly in recent decades, leveraging the
unique phenomenon known as the enhanced permeability and retention (EPR) effect. This …