Metastasis causes most cancer-related deaths; however, the efficacy of anti-metastatic drugs
is limited by incomplete understanding of the biological mechanisms that drive metastasis …

The term 'mechanosensation'describes the capacity of cells to translate mechanical stimuli
into the coordinated regulation of intracellular signals, cellular function, gene expression …

Matrix stiffening and external mechanical stress have been linked to disease and cancer
development in multiple tissues, including the liver, where cirrhosis (which increases …

Nuclear pore complexes (NPCs) direct the nucleocytoplasmic transport of macromolecules.
Here, we provide a composite multiscale structure of the yeast NPC, based on improved 3D …

Cells sense physical forces and convert them into electrical or chemical signals, a process
known as mechanotransduction. Whereas extensive studies focus on mechanotransduction …

Physical forces are ubiquitous in biological processes across scales and diverse contexts.
This review highlights the significance of mechanical forces in nervous system development …

Physical forces are essential to biological function, but their impact at the tissue level is not
fully understood. The gut is under continuous mechanical stress because of peristalsis. To …

The cellular microenvironment is highly heterogeneous and dynamic. Therefore, cells must
be equipped with molecular tools to adapt and respond to constantly fluctuating inputs. One …

All life forms sense and respond to mechanical stimuli. Throughout evolution, organisms
develop diverse mechanosensing and mechanotransduction pathways, leading to fast and …

Cells tune adherens junction dynamics to regulate epithelial integrity in diverse (patho)
physiological processes, including cancer metastasis. We hypothesized that the spatially …