Suicide biomarkers to predict risk, classify diagnostic subtypes, and identify novel therapeutic targets: 5 years of promising research

JN Johnston, D Campbell, HJ Caruncho… - International journal …, 2022 - academic.oup.com
Background Suicide is a global health crisis. However, no objective biomarkers of suicide
risk currently exist, and self-reported data can be unreliable, which limits prediction …

Comorbidity between Alzheimer's disease and major depression: a behavioural and transcriptomic characterization study in mice

A Martín-Sánchez, J Piñero, L Nonell, M Arnal… - Alzheimer's Research & …, 2021 - Springer
Background Major depression (MD) is the most prevalent psychiatric disease in the
population and is considered a prodromal stage of the Alzheimer's disease (AD). Despite …

IRON METABOLISM DYSFUNCTION IN NEUROPSYCHIATRIC DISORDERS: IMPLICATIONS FOR THERAPEUTIC INTERVENTION

E Duarte-Silva, M Maes, CA Peixoto - Behavioural Brain Research, 2024 - Elsevier
Iron is a trace metal that takes part in the maintenance of body homeostasis by, for instance,
aiding in energy production and immunity. A body of evidence now demonstrates that …

Iron aggravates the depressive phenotype of stressed mice by compromising the glymphatic system

S Liang, Y Lu, Z Li, S Li, B Chen, M Zhang, B Chen… - Neuroscience …, 2020 - Springer
The pathophysiological mechanisms underlying mood disorders including major depressive
disorder (MDD) remain to be fully characterized. Iron is a key component in the development …

Higher levels of AKT-interacting protein in the frontal pole from people with schizophrenia are limited to a sub-group who have a marked deficit in cortical muscarinic …

M Snelleksz, B Dean - Psychiatry Research, 2024 - Elsevier
We are studying the molecular pathology of a sub-group within schizophrenia (∼ 25%:
termed Muscarinic Receptor Deficit subgroup of Schizophrenia (MRDS)) who can be …

Potential biomarkers for diagnosing major depressive disorder patients with suicidal ideation

S Bai, L Fang, J Xie, H Bai, W Wang… - Journal of inflammation …, 2021 - Taylor & Francis
Background Major depressive disorder (MDD) and suicide are two major health problems,
but there are still no objective methods to diagnose MDD or suicidal ideation (SI). This study …

Metallomics‐based platforms for comparing the human blood serum profiles between bipolar disorder and schizophrenia patients

G de Souza Pessôa, JR de Jesus… - Rapid …, 2020 - Wiley Online Library
Rationale An evaluation of bipolar disorder (BD) and schizophrenia (SCZ) was carried out,
from a metallomics point of view, using native conditions, attempting to preserve the …

Label-Free Liquid Chromatography–Mass Spectrometry Proteomic Analysis of the Urinary Proteome for Measuring the Escitalopram Treatment Response From Major …

Y Huan, J Wei, J Zhou, M Liu, J Yang, Y Gao - Frontiers in psychiatry, 2021 - frontiersin.org
Major depressive disorder (MDD) is a common mental disorder that can cause substantial
impairments in quality of life. Clinical treatment is usually built on a trial-and-error method …

Machine learning analysis of blood microRNA data in major depression: A case-control study for biomarker discovery

B Qi, LM Fiori, G Turecki… - International Journal of …, 2020 - academic.oup.com
Background There is a lack of reliable biomarkers for major depressive disorder (MDD) in
clinical practice. However, several studies have shown an association between alterations …

Depression and suicide risk in mild cognitive impairment: the role of Alzheimer's disease biomarkers

I Ferrer-Cairols, N Martín, A Cuevas, M Baquero… - 2022 - zaguan.unizar.es
Depression and Suicide Risk in Mild Cognitive Impairment: The Role of Alzheimer’s
Disease Biomarkers Page 1 553 ABSTRACT Depression and Suicide Risk in Mild …