Old drugs, new tricks: leveraging known compounds to disrupt coronavirus-induced cytokine storm

S Richman, C Lyman, A Nesterova, A Yuryev… - NPJ Systems Biology …, 2022 - nature.com
A major complication in COVID-19 infection consists in the onset of acute respiratory distress
fueled by a dysregulation of the host immune network that leads to a run-away cytokine …

A Computational Protocol for the Knowledge-Based Assessment and Capture of Pathologies

J Page, N Moore, G Broderick - Psychoneuroimmunology: Methods and …, 2024 - Springer
We propose that one of the main hurdles in delivering comprehensively informed care
results from the challenges surrounding the extraction, representation, and retention of prior …

Attractor landscapes as a model selection criterion in data poor environments

CA Lyman, S Richman, MC Morris, H Cao, A Scerri… - bioRxiv, 2021 - biorxiv.org
Modeling of systems for which data is limited often leads to underdetermined model
identification problems, where multiple candidate models are equally adherent to data. In …

[图书][B] BioDOV: A Tool Used to Encourage Discovery in Bioinformatics Through Gamification

GD Johnson Jr - 2023 - search.proquest.com
Expressing big data in a meaningful manner is exceptionally difficult. Scientists often
struggle with the visualization of data due to several limitations. Currently, many scientists …

[图书][B] An Exploratory Assessment of Peer-reviewed Life Science Literature Statement Readability Used in Text-based Interpretive Analyses

J Jackson - 2021 - search.proquest.com
This project looked to explore the process of one of the scientific community's leading text
mining software, Pathway Studio, which efficiently streamlines the tedious task of information …

Leveraging Drug-Target Interaction Data for the Translation of Computational Models into Clinically Actionable Interventions

SC Richmanz, CA Lyman, MC Morris… - 2021 IEEE …, 2021 - ieeexplore.ieee.org
Computational modeling is an effective tool for studying complex disease. However,
solutions to many models are purely mathematical and cannot immediately provide clinical …