Neuroendocrine prostate cancer (NEPC) is a lethal subtype of prostate cancer. NEPC arises
de novo only rarely; the disease predominantly develops from adenocarcinoma in response …

The vertebrate spinal cord comprises multiple functionally distinct neuronal cell types
arranged in characteristic positions. During development, these different types of neurons …

Neuroblastoma (NB), which is a subtype of neural-crest-derived malignancy, is the most
common extracranial solid tumor occurring in childhood. Despite extensive research, the …

The coordinated spatial and temporal regulation of gene expression in the vertebrate neural
tube determines the identity of neural progenitors and the function and physiology of the …

Motor neurons (MNs) are neuronal cells located in the central nervous system (CNS)
controlling a variety of downstream targets. This function infers the existence of MN subtypes …

In vertebrates, motor control relies on cholinergic neurons in the spinal cord that have been
extensively studied over the past hundred years, yet the full heterogeneity of these neurons …

The molecular mechanisms that produce the full array of neuronal subtypes in the vertebrate
nervous system are incompletely understood. Here, we provide evidence of a global …

Abstract The transcription factors, Smad1, Smad5 and Smad8, are the pivotal intracellular
effectors of the bone morphogenetic protein (BMP) family of proteins. BMPs and their …

Previously, we have shown that Onecut1 (Oc1) and Onecut2 (Oc2) are expressed in retinal
progenitor cells, developing retinal ganglion cells (RGCs), and horizontal cells (HCs) …

The development of the vertebrate spinal cord involves the formation of the neural tube and
the generation of multiple distinct cell types. The process starts during gastrulation …