Solid tumors carry out the formation of new vessels providing blood supply for growth, tumor
maintenance, and metastasis. Several processes take place during tumor vascularization. In …

Drug delivery systems for cancer therapeutics have revolutionized medicine. Delivery
systems have improved the efficacy and reduced the toxicity of current therapies and …

Embryonic exposure to thalidomide (THAL) or valproic acid (VPA) before neural tube
closure has been demonstrated as a useful model for human autism in rats. Abnormalities of …

PEGylation of IFN-α has been used successfully to improve the pharmacokinetic properties
and efficacy of the drug. To prepare a PEGylated form of human interferon-β-1a (IFN-β-1a) …

The metalloprotease ADAMTS9 participates in melanoblast development and is a tumor
suppressor in esophageal and nasopharyngeal cancer. ADAMTS9 null mice die before …

Interferons (IFNs) are a large family of pleiotropic cytokines that regulate both innate and
adaptive immunity and show anti-cancer effects in various cancer types. Moreover, it was …

Interferon-α (IFN-α) is well established in the treatment of neuroendocrine carcinomas
(NEC). Treatment is accompanied by fatigue and flu-like symptoms. In patients with chronic …

PBRM1, a subunit of the PBAF coactivator complex that transcription factors use to activate
target genes, is genetically inactivated in almost all clear cell renal cell cancers (RCCs) …

Until now little information is available about bone marrow (BM) angiogenesis in chronic
myeloproliferative disorders (CMPDs). Amongst the various immunohistochemical markers …

Bone is a common site of osteolytic and richly vascularized metastases of renal cell
carcinoma (RCC) and Interferon (IFN)-α based therapies have been considered for the …