Rheumatoid arthritis (RA) is an autoimmune disease that is more common in women than in
men. The peak incidence in females coincides with menopause when the ovarian …

The human inflammatory response can result in the alteration of drug clearance through
effects on drug‐metabolizing enzymes or drug transporters. In this article, clinical examples …

The IL-6/GP130/STAT3 pathway is critical for the progression of multiple types of cancers.
We report here the discovery of raloxifene and bazedoxifene as novel inhibitors of IL …

The loss of estrogen (E2) initiates a rapid phase of bone loss leading to osteoporosis in one‐
half of postmenopausal women, but the mechanism is not fully understood. Here, we show …

Growing interest in gut and digestive processes and their potential link to brain and
peripheral based inflammation or biobehavioral phenotypes has led to an increasing …

Introduction: Osteoporosis is a common disease characterized by the occurrence of fragility
fractures. Major osteoporotic fractures are associated with decreased quality of life and high …

BACKGROUND & AIMS: Early menopause in women with chronic hepatitis C virus (HCV)
infection is associated with a low likelihood of a sustained virological response (SVR) in …

The new coronavirus SARS-CoV-2 is the causative agent of the COVID-19 pandemic, which
so far has caused over 6 million deaths in 2 years, despite new vaccines and antiviral …

Postmenopausal osteoporosis (PMOP) is a metabolic disease that leads to the decrease of
estrogen level in women, Resultsing in the osteoclastic bone resorption over osteoblastic …

Overexpression of transforming growth factor-beta 1 (TGF-β1) and subchondral bone
remodeling play key roles in osteoarthritis (OA). Raloxifene (RAL) reduces the serum level of …