Objective: To review the assays available for measurement of nitrite and nitrate ions in body
fluids and their clinical applications. Design and Methods: Literature searches were done of …

Research on the free radical gas, nitric oxide (NO), during the past twenty years is one of the
most rapid growing areas in biology. NO seems to play a part in almost every organ and …

The mechanisms that initiate liver regeneration after resection of liver tissue are not known.
To determine whether cytokines are involved in the initiation of liver growth, we studied the …

Complement has been implicated in liver repair after toxic injury. Here, we demonstrate that
complement components are essential for liver regeneration, and mediate their effect by …

Acetaminophen is a mild analgesic and antipyretic agent known to cause centrilobular
hepatic necrosis at toxic doses. Although this may be due to a direct interaction of reactive …

Cell division and subsequent programmed cell death in imaginal discs of Drosophila larvae
determine the final size of organs and structures of the adult fly. We show here that nitric …

The growth‐stimulatory actions of tumor necrosis factor α (TNF‐α) after partial hepatectomy
(PH) are difficult to reconcile with its well‐established role in the genesis of liver injury. The …

Most of the carbon monoxide (CO) produced by mammals is a product of the heme
oxygenase (HO) reaction, the rate-limiting step in the heme degradation pathway leading to …

Mechanisms controlling the transition of precursor cells from proliferation to differentiation
during organism development determine the distinct anatomical features of tissues and …

The present invention is based on the discovery that nitric oxide (NO) is an important growth
regulator in an intact developing organism. In particular, the present invention relates to a …