Unravelling the enigma of siRNA and aptamer mediated therapies against pancreatic cancer

Z Liu, N Parveen, U Rehman, A Aziz, A Sheikh… - Molecular Cancer, 2023 - Springer
Pancreatic cancer (PC) is a fatal disease that has a poor 5-year survival rate. The poor
prognosis can be attributed to both troublesome detections at the initial stage, which makes …

Cancer metabolites: promising biomarkers for cancer liquid biopsy

W Wang, Z Rong, G Wang, Y Hou, F Yang, M Qiu - Biomarker Research, 2023 - Springer
Cancer exerts a multitude of effects on metabolism, including the reprogramming of cellular
metabolic pathways and alterations in metabolites that facilitate inappropriate proliferation of …

A sustainable approach to universal metabolic cancer diagnosis

R Wang, S Yang, M Wang, Y Zhou, X Li, W Chen… - Nature …, 2024 - nature.com
Over a billion people across the world experience a high rate of missed disease diagnosis,
an issue that highlights the need for diagnostic tools showing increased accuracy and …

Unbiasedly decoding the tumor microenvironment with single-cell multiomics analysis in pancreatic cancer

Y Fu, J Tao, T Liu, Y Liu, J Qiu, D Su, R Wang, W Luo… - Molecular Cancer, 2024 - Springer
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a poor
prognosis and limited therapeutic options. Research on the tumor microenvironment (TME) …

Advanced mass spectrometric and spectroscopic methods coupled with machine learning for in vitro diagnosis

X Chen, W Shu, L Zhao, J Wan - View, 2023 - Wiley Online Library
In vitro diagnosis (IVD) is one vital component of medical tests that detects biological
samples of tissues or bio‐fluids. Recently, mass spectrometry and spectroscopy have been …

Data-driven modeling methods and techniques for pharmaceutical processes

Y Dong, T Yang, Y Xing, J Du, Q Meng - Processes, 2023 - mdpi.com
As one of the most influential industries in public health and the global economy, the
pharmaceutical industry is facing multiple challenges in drug research, development and …

[HTML][HTML] Cellular metabolism in pancreatic cancer as a tool for prognosis and treatment

M Zuzčák, J Trnka - International Journal of Oncology, 2022 - spandidos-publications.com
Pancreatic cancer (PC) has one of the highest fatality rates and the currently available
therapeutic options are not sufficient to improve its overall poor prognosis. In addition to …

Targeted inhibition of CHKα and mTOR in models of pancreatic ductal adenocarcinoma: A novel regimen for metastasis

J Liu, B Jiang, W Xu, Q Liu, H Huang, X Chang, G Ma… - Cancer letters, 2024 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic malignancy for which there
are currently no effective anti-metastatic therapies. Herein, we employed single-cell RNA …

Applications of liquid chromatography-mass spectrometry based metabolomics in predictive and personalized medicine

J Zhou, L Zhong - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
Metabolomics is a fast-developing technique used in biomedical researches focusing on
pathological mechanism illustration or novel biomarker development for diseases. The …

Machine learning Encodes urine and serum metabolic patterns for autoimmune disease discrimination, classification and metabolic dysregulation analysis

Q Du, X Wang, J Chen, Y Wang, W Liu, L Wang, H Liu… - Analyst, 2023 - pubs.rsc.org
There is a wide variety of autoimmune diseases (ADs) with complex pathogenesis and their
accurate diagnosis is difficult to achieve because of their vague symptoms. Metabolomics …