Despite encouraging progress over the past decade, malaria remains a major global health
challenge. Its severe form accounts for the majority of malaria-related deaths, and early …

Cerebral malaria (CM) is a major cause of mortality in Plasmodium falciparum (Pf) infection
and is associated with the sequestration of parasitised erythrocytes in the microvasculature …

Importance The emergence of acute neurological symptoms in children necessitates
immediate intervention. Although low-and middle-income countries (LMICs) bear the highest …

Introduction Malaria remains a significant public health problem in sub-Saharan Africa. Child
mortality due to severe malaria remains high in developing countries despite improvements …

The key to reducing malaria deaths in highly endemic areas is prompt access to quality case
management. Given that many severe cases occur at peripheral level, rectal artesunate …

The relationship between community prevalence of Plasmodium falciparum and the burden
of severe, life-threatening disease remains poorly defined. To examine the three most …

Background For a full treatment course of severe malaria, community-administered pre-
referral rectal artesunate (RAS) should be completed by post-referral treatment consisting of …

Background Understanding the age patterns of disease is necessary to target interventions
to maximise cost-effective impact. New malaria chemoprevention and vaccine initiatives …

Background Malaria is one of the most common causes of hospital admission and death in
children under the age of five. The World Health Organization (WHO) has issued guidelines …

Nigeria accounts for 39% of global malaria deaths in children under 5 years of age and the
effective management of severe malaria is a health priority. The Annual Nigeria Severe …