Association between genetic polymorphisms and risk of adolescent idiopathic scoliosis in case-control studies: a systematic review

E Terhune, P Heyn, C Piper, C Wethey… - Journal of Medical …, 2024 - jmg.bmj.com
Background Adolescent idiopathic scoliosis (AIS) is a structural lateral spinal curvature of≥
10° with rotation. Approximately 2%–3% of children across populations are affected with …

The role of muscle biomarkers in adolescent idiopathic scoliosis

F Roggio, B Trovato, M Sortino, MP Onesta… - Journal of Clinical …, 2023 - mdpi.com
Adolescent idiopathic scoliosis (AIS) is the predominant orthopedic disorder in children,
affecting 1–3% of the global population. Research in this field has tried to delineate the …

Association of vitamin D receptor BsmI rs1544410 and ApaI rs7975232 polymorphisms with susceptibility to adolescent idiopathic scoliosis: a systematic review and …

X Yin, H Wang, J Guo, L Zhang, Y Zhang, L Li, S Hou - Medicine, 2018 - journals.lww.com
Background: AIS is the most common spinal deformity disease, yet its etiology remains
uncertain. Significant associations have been found between AIS risk and vitamin D receptor …

Association of renalase SNPs rs2296545 and rs2576178 with the risk of hypertension: a meta-analysis

YB Lv, Y Wang, WG Ma, DY Yan, WL Zheng, C Chu… - PLoS …, 2016 - journals.plos.org
Background/Aims Two renalase single nucleotide polymorphisms (SNPs) rs2296545 and
rs2576178 have been reported to be associated with the susceptibility to hypertension (HT) …

Severity of idiopathic scoliosis is associated with differential methylation: An epigenome-wide association study of monozygotic twins with idiopathic scoliosis

PM Carry, EA Terhune, GD Trahan, LA Vanderlinden… - Genes, 2021 - mdpi.com
Epigenetic mechanisms may contribute to idiopathic scoliosis (IS). We identified 8
monozygotic twin pairs with IS, 6 discordant (Cobb angle difference> 10°) and 2 concordant …

Whole exome sequencing of 23 multigeneration idiopathic scoliosis families reveals enrichments in cytoskeletal variants, suggests highly polygenic disease

EA Terhune, CI Wethey, MT Cuevas, AM Monley… - Genes, 2021 - mdpi.com
Adolescent idiopathic scoliosis (AIS) is a lateral spinal curvature> 10° with rotation that
affects 2–3% of healthy children across populations. AIS is known to have a significant …

Deletion of a conserved genomic region associated with adolescent idiopathic scoliosis leads to vertebral rotation in mice

J McCallum-Loudeac, E Moody… - Human molecular …, 2024 - academic.oup.com
Adolescent idiopathic scoliosis (AIS) is the most common form of scoliosis, in which spinal
curvature develops in adolescence, and 90% of patients are female. Scoliosis is a …

The susceptibility and potential functions of the LBX1 gene in adolescent idiopathic Scoliosis

M Luo, Y Zhang, S Huang, Y Song - Frontiers in Genetics, 2021 - frontiersin.org
Genome-wide association studies have identified many susceptibility genes for adolescent
idiopathic scoliosis (AIS). However, most of the results are hard to be replicated in multi …

Associations of LBX1 gene and adolescent idiopathic scoliosis susceptibility: a meta-analysis based on 34,626 subjects

Y Cao, J Min, Q Zhang, H Li, H Li - BMC musculoskeletal disorders, 2016 - Springer
Background The results of studies investigating the association between the ladybird
homeobox 1 (LBX1) gene polymorphisms and the risk of adolescent idiopathic scoliosis …

Association between the estrogen receptor beta (ESR2) Rs1256120 single nucleotide polymorphism and adolescent idiopathic scoliosis: a systematic review and …

L Zhao, DM Roffey, S Chen - Spine, 2017 - journals.lww.com
Study Design. A systematic review and meta-analysis. Objective. The aim of this study was
to assess and synthesize the current evidence on the association between the rs1256120 …