Abstract The phosphodiesterase 4 (PDE4) enzyme family plays a pivotal role in regulating
levels of the second messenger cAMP. Consequently, PDE4 inhibitors have been …

Phosphodiesterases (PDEs) are a class of enzymes that hydrolyze cyclic adenosine
monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) which is involved in …

Phosphodiesterases (PDEs) have been an interesting drug target for many diseases.
Although a vast number of mainly preclinical studies demonstrates beneficial effects of PDE …

Novel pyridine-and pyrimidine-based allosteric inhibitors are reported that achieve PDE4D
subtype selectivity through recognition of a single amino acid difference on a key regulatory …

Sensorimotor recovery following ischemic stroke is highly related with structural modification
and functional reorganization of residual brain tissues. Manipulations, such as treatment …

Abstract Disrupted in schizophrenia 1 (DISC1) is a multi-functional scaffolding protein that
has been associated with neuropsychiatric disease. The role of DISC1 is to assemble …

In Eukaryotes, more than 100 different phosphodiesterase (PDE) proteins serve to fine-tune
cyclic nucleotide (cAMP and cGMP) signals and contribute to specificity of signaling. In …

Background: There is an acute need to uncover biomarkers that reflect the molecular
pathologies, underpinning prostate cancer progression and poor patient outcome. We have …

Human PDE4D isoform composition is deregulated in primary prostate cancer and indicative
for disease progression and development of distant metastases - PMC Back to Top Skip to …

A robust body of work has demonstrated that a reduction in cAMP‐specific 3′, 5′‐cyclic
phosphodiesterase 4D isoform 7 (PDE4D7) is linked with negative prostate cancer …